CellCircuits: From 130 genome-wide screens to a map cellular regulation
Are you a computational biologist?
Are you fascinated by cellular regulation?
Are you looking for an opportunity to discover new therapeutic strategies?
Then this position might be exactly what you were looking for!
Project description. Human cells perform highly complex tasks but the map of cellular regulation that controls these processes is surprisingly poorly known. We will employ Phenosaurus, a large collection ~130 genome-wide haploid screens and advanced computational (network) inference approaches to reconstruct this map. The superior quality, breadth and depth of Phenosaurus, provide an unprecedented opportunity to tackle this challenging task. At the core of this project is a close collaboration between wet and dry lab scientists, aimed at validating predictions and generating bespoke data to accelerate map generation.
The consortium. This consortium is a collaboration involving Scenic Biotech BV (CellSeq technology), the Brummelkamp laboratory (haploid screening, cell and molecular biology) and the Wessels laboratory (computational know-how). The successful candidate will be employed in both the Wessels and Brummelkamp groups at the Netherlands Cancer Institute, and will regularly liaise with Scenic Biotech to generate sufficient cohesion and momentum.
Candidate profile. We are seeking a highly motivated Postdoc candidate with:
• A degree in bioinformatics, computer science or a related discipline
• A degree or a very keen interest in (molecular) biology
• Proficiency in R, Python and data base management
• Experience in interacting with molecular biologists
Interested? Please send CV and motivation letter to Lodewyk Wessels (firstname.lastname@example.org). Please include the names and contact information of at least two references.
Deadline: 6 January 2020
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- Mezzadra et al. (2017) Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 549, 106-110.