How are cellular networks regulated?
Understanding the basic molecular regulatory mechanisms that underlie the cancer landscape is important for several reasons. First, it allows more accurate intervention to reach the desired therapeutic effect. Second, it is essential for understanding the functional oncogenic role of spontaneously occurring somatic and germline variants as well as artificially induced perturbations routinely used in genetic screens such as insertional mutagenesis screens. Gene regulatory elements and local chromatin context are indeed important determinants of the effects of mutations on neighboring genes. Similarly, miRNAs are important regulators of target genes, thus impacting the larger genetic network and subsequently oncogenesis and therapy response.
- Regulatory elements and chromatin context
- Expression regulation by miRNAs
- Multi-level Bayesian modeling of cell line drug response
- Cancer-specific metabolic regulations and vulnerabilities